Function of the follicular dendritic cell in the germinal center of lymphoid follicles. Imai Y, Yamakawa M, Masuda A, Sato T, Kasajima T.Retention of immune complexes by murine lymph node or spleen follicular dendritic cells. Heinen E, Coulie P, Van Snick J, Braun M, Cormann N, Moeremans M, Kinet-Denoel C, Simar LJ.Follicular dendritic cells in suspension: identification, enrichment, and initial characterization indicating immune complex trapping and lack of adherence and phagocytic activity. Schnizlein CT, Kosco MH, Szakal AK, Tew JG. Isolated follicular dendritic cells: cytochemical antigen localization, Nomarski, SEM, and TEM morphology. Szakal AK, Gieringer RL, Kosco MH, Tew JG.The normal and malignant germinal centre. Virchows Arch B Cell Pathol Incl Mol Pathol. A study using monoclonal and heterologous antibodies. Analysis of lymphoid and dendritic cells in human lymph node, tonsil and spleen. van der Valk P, van der Loo EM, Jansen J, Daha MR, Meijer CJ.Links to PubMed are also available for Selected References. Get a printable copy (PDF file) of the complete article (2.6M), or click on a page image below to browse page by page. Full textįull text is available as a scanned copy of the original print version. Our data indicate that there is an evident functional difference between the light zone and the dark zone, and that complete activation of the complement system occurs only in the light zone. All four complement regulatory proteins were localized by immunoelectron microscopy attached to the cell surface of the cells, including follicular dendritic cells, in the light zone. The second group was characterized by a diffusely weak to moderate dendritic meshwork pattern of the dark zone to some of the immunostainings of C9 (monoclonal), S-protein, and DF-DRC1, and all immunostainings of CR1 (CD35), Ber-Mac-DRC (CD35), CR2 (CD21), and R4/23. One immunostaining pattern was characterized by no immunostaining of the dark zone to the majority of the antigens. The immunostaining patterns were classified into two major groups based on the immunoreactivity of the dark zone. The light zones were consistently immunostained in a dendritic meshwork pattern with all antibodies. Sixty secondary lymphoid follicles with evident polarity, that is, the distinct coexistence of a light zone, dark zone and mantle zone in the same lymphoid follicle, were tested with single antibodies. Peyer's patches and tonsils were analysed. Fifteen lymphoid tissues including appendices. A comparative immunohistochemical study of the distribution pattern of complement components and regulatory proteins within secondary lymphoid follicles was performed by the immunoperoxidase technique.
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